Peer Review Request - Decline Confirmation
BMS-CTMC-2024-169
Article Title:
Innovative Therapies: A Major Breakthrough in Combating Multi-Drug-resistant Bacterial Infections Using Mixture Design and Multi-Objective Optimization with NSGA-II Algorithm
Abstract:
Introduction/Objective: The increasing resistance of pathogens to antibiotics poses a major public health challenge. This study aims to develop an innovative approach to combat this resistance by exploring synergies between standard antibiotics and marine metabolites.
Methods: The methodology combines disk diffusion testing and mixture design to assess the antimicrobial efficacy of the combinations.
Results and Discussion: The results demonstrate promising synergies between carotenoids, polyphenols, and alkaloids with standard antibiotics, offering potential targeted use in the fight against clinical multidrug-resistant bacteria. Specifically, Gram-negative bacteria (BGN) showed increased resistance to antibiotics such as amoxicillin-clavulanic acid (AMC), ceftazidime, cefotaxime, tetracycline, and cefazolin. These antibiotics, when combined with marine compounds, exhibited substantial inhibitory effects against specific isolates, circumventing antibiotic resistance mechanisms. Similarly, substantial synergies were observed in Gram-positive bacteria.